Are braces allowed within the NDA

Transcranial magnetic stimulation in focal hand dystonia

Eligibility to participate

Criteria:

- INCLUSION CRITERIA:

- Confirmed diagnosis of focal hand dystonia (patients only).

- Between 18 and 70 years.

- Can give a declaration of consent

- right handed

- agrees not to drink caffeine or alcohol for 48 hours prior to the study session.

- No open scalp wounds or scalp infections.

EXCLUSION CRITERIA:

- Has used illicit drugs for the past 6 months based on history including but not limited to marijuana, cocaine, methamphetamine, etc. The intent is to exclude these with drug use which may affect study results. Participants who appear to be drunk at the time of the test will be postponed.

- Has more than 7 alcoholic drinks a week for a woman and 14 alcoholic drinks a week for a man.

- Abnormal findings on neurological examination (except for dystonia in the patient group)

- Has a brain tumor, stroke, traumatic brain injury, epilepsy, or a history of seizures.

- Has severe depression or any severe mental disorders (Axis I disorders)

- Has a neurological disorder other than dystonia

- Has had a head injury that has passed unconscious for more than a few seconds.

- Has a pacemaker, intracardiac lines, implanted pumps or stimulators, or has metal objects in the eye or skull. Dental fillings and braces are allowed.

- Has a known hearing loss.

- pregnancy

- Taking medications that act as central nervous system stimulants or are known to lower seizure threshold, including imipramine, amitriptyline, doxepin, nortriptyline, maprotiline, chlorpromazine, clozapine, foscarnet, ganciclovir, ritonavir, amphetamines, cocaine (MDMA, ecstasyidine) (PCP, angel dust), ketamine, gamma-hydroxybutyrate (GHB), alcohol, theophylline, mianserin, fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram, reboxetine, venlafaxine, duloxetine, bupropion, mirtazapine, quupidanzapine, poperimine , Aripiprazole, ziprasidone, risperidone, chloroquine, mefloquine, imipenem, penicillin, ampicillin, cephalosporins, metronidazole, isoniazid, levofloxacin, cyclosporin, chlorambucil, vincristine, methotrexatinos, lithium, antioxidants, cytosine-arabic drugs, anti-sympathetic drugs, anticholimine drugs.

- Has excessive daytime sleepiness as indicated by a score of 10 or higher on the Epworth Sleepiness Scale.

Gender:

Everything

Minimum age:

18 years

Maximum age:

70 years

Healthy volunteers:

Accepts healthy volunteers