What is high LH

At the Luteinizing hormone (LH or also called lutropin) is a hormone from the pituitary gland, which, with the help of the follicle-stimulating hormone (FSH), causes follicle maturation (egg cell maturation) and ovulation (ovulation) in the Mrs controls. It is also involved in the synthesis of estrogen and progesterone.

At the man The LH (Interstitial Cell Stimulating Hormones = ICSH) controls the production of androgens in the testes.

The LH itself is controlled by the gonadotropin-releasing hormone (GRH), which is produced in the hypothalamus.

The LH shows a cycle-dependent rhythm with a strong peak in the middle of the cycle. It is released in a pulsatile manner, the basal LH values ​​fluctuate greatly during the day from puberty and in women up to menopause.

The procedure

Required material

  • Blood serum
  • The best time to take blood samples for women: 2-5 days after the start of menstruation; to record the time of ovulation (ovulation) blood sampling in the middle of the cycle
  • Note: Determination in women from pool serum can be advantageous because of the pulsatile release of the LH

Prepare the patient

Disruptive factors

Normal values ​​children

AgeStandard values ​​in U / l
2nd-12th Day of life (LT)< 0,1-0,5
Age 2-11 (LJ)< 0,1-0,4
12-13 LJ< 0,1-5,4
14.-18. LJ0,5-12,9

Normal values ​​women

cycleStandard values ​​in U / l
Follicular phase2-6
ovulation6-20
Luteal phase3-8
menopause> 30

Normal values ​​men

cycleStandard values ​​in U / l
Prepubescent0,2-0,8
Post-puberty0,8-8,3

Indications

  • Sterility diagnostics
  • Suspected ovarian failure - functional weakness of the ovaries such as disorders of puberty or menopause (menopause)
  • Suspected testicular insufficiency (hypogonadism; DD hypo- or hypergonadotropic) - functional weakness of the testes as a hormone-producing organ
  • Spermatogenesis disorder (sperm cell formation)
  • Disorders of the development of puberty (of men) - pubertas tarda; Precocious puberty

interpretation

Interpretation of elevated values ​​in women

  • Gonadal dysgenesis (e.g. Turner syndrome) - malformation of the gonads
  • Climacterium praecox (premature menopause) - menopause that occurs too early; between the ages of 25 and 40
  • Ovulation (ovulation)
  • Medicinal administration of human chorionic gonadotropin (HCG) - pregnancy hormone
  • Polycystic Ovary Syndrome (PCO syndrome) - a condition that causes hormonal changes by the appearance of multiple cysts on the ovaries
  • Postmenopausal - condition after menopause
  • Cytostatic therapy - drugs that are mainly used in cancer

Interpretation of elevated values ​​in men

  • Androgen resistance (testosterone ↑)
  • Primary testicular failure
    • Testicular atrophy - testicular shrinkage; leads to limited or completely eliminated sperm production
    • Inguinal testicles
    • Leydig cell dysfunction
  • Hypergonadotropic hypogonadism (gonadal dysgenesis) - malformation of the gonads

Interpretation of lowered values ​​in women

  • Secondary ovarian failure
    • Anorexia nervosa (anorexia)
    • Olfactogenital Syndrome (Kallmann) - genetic disease based on a lack of sex hormones
  • Hyperprolactinemia - excessive levels of prolactin in the blood
  • McCune-Albright syndrome - combination of fibroplasia, pigment disorders, and hormone dysfunction
  • Sex steroid therapy (hormonal contraceptives; hormone replacement therapy) - drug therapy with ovulation inhibitors ("pill") or the use of sex steroids

Interpretation of lowered values ​​in men

  • Hypogonadotropic hypogonadism (testosterone ↓) - underactive gonads due to hypothalamic or pituitary disorders
  • Secondary testicular insufficiency (testosterone ↓) - disruption of hormone production by the testicle
  • Testosterone therapy (testosterone is normal to elevated)

More information

  • When interpreting the measured values, the cycle phase must always be taken into account, i. H. It is always necessary to state the day of the cycle on the day the blood was taken or the first day of the last menstrual period.
  • LH should always be determined in combination with FSH

     
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